Phenotypes Associated with This Genotype

Genotype
MGI:5788422

• Allelic Composition: Tg(TNFSF11)5516Edou/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal trabecular bone morphology ( J:233240 )

• subtle trabecular bone loss at 4 weeks of age and pronounced loss at 2 and 3 months of age

• however, mid-diaphysis cortical bone volume and thickness are normal

decreased trabecular bone volume ( J:233240 )

• trabecular bone volume fraction is reduced nearly 2.5-fold

decreased bone trabecula number ( J:233240 )

• trabecular number is reduced more than 50% in 3 month old mice

increased bone trabecular spacing ( J:233240 )

• mutants exhibit wider trabecular separation (245%) than wild-type mice

decreased trabecular bone connectivity density ( J:233240 )

• trabecular connectivity density is decreased by 6-fold

osteoporosis ( J:233240 )

• mice develop mild osteoporosis characterized by trabecular bone loss and decreased bone strength by 3 months of age

decreased femur stiffness ( J:233240 )

• 34% reduction in stiffness of mid-diaphysis femurs from 3 month old mice

decreased bone strength ( J:233240 )

• mid-diaphysis femurs from 3-month old mice have reduced biomechanical properties, with a 22% reduction in ultimate force, 34% reduction in stiffness, 23% reduction in plastic energy

• however, markers of bone turnover and serum alkaline phosphatase levels are normal