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Phenotypes Associated with This Genotype
Genotype
MGI:5784767
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Tg(TPO-cre)1Shk/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal thyroid gland morphology ( J:231492 )
• about 65% of mice exhibit mild nodular hyperplasia after 18 months

neoplasm
neoplasm ( J:231492 )
N
• mice do not develop thyroid cancer

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory