Phenotypes Associated with This Genotype

Genotype
MGI:5784746

• Allelic Composition: Crebrf^{Gt(YHD319)Byg}/Crebrf^{Gt(YHD319)Byg}
• Genetic Background: B6.129P2-Crebrf^{Gt(YHD319)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:192857 )

♀ • female mice spend less time in the dark side of a light-dark box compared with wild-type mice

limb grasping ( J:192857 )

• severe

hyperactivity ( J:192857 )

♀ • in female mice

increased vertical activity ( J:192857 )

♀ • in female mice

abnormal maternal nurturing ( J:192857 )

♀ • dams exhibit maternal neglect such that pups found outside of the nest and/or lack milk spots with evidence of infanticide

♀ • during the pup retrieval test, nulliparous females exhibit increased non-pup-related activities (nest building, digging and exploring) compared with wild-type mice

♀ • however, cross-fostered pups exhibit improved survival and supplementation with prolactin or growth hormone repression by RU486 restores maternal behavior

abnormal social investigation ( J:192857 )

♀ • female mice exhibit impaired social recognition compared with wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:192857 )

♀N • female mice exhibit normal plasma levels of corticosterone and oxytocin

decreased circulating corticosterone level ( J:192857 )

♀ • 12-fold by 5 days postpartum in female mice

decreased circulating prolactin level ( J:192857 )

♀ • pre- and postpartum in female mice

growth/size/body

decreased body size ( J:192857 )

decreased body weight ( J:192857 )

• in male and female mice at 6 months

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:192857 )

♀ • primiparous lactating dams exhibit decreased density of terminally differentiated gland tissue compared with wild-type mice

integument

abnormal mammary gland growth during lactation ( J:192857 )

♀ • primiparous lactating dams exhibit decreased density of terminally differentiated gland tissue compared with wild-type mice