Phenotypes Associated with This Genotype

Genotype
MGI:5781120

• Allelic Composition: Col25a1^tm1.1Tiwa/Col25a1^tm1.1Tiwa
• Genetic Background: B6.Cg-Col25a1^tm1.1Tiwa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:206855 )

• despite being viable at E18.5, mice die shortly after birth

nervous system

abnormal motor neuron morphology ( J:206855 )

• at E18.5, mice have few spinal cord motor neuron of smaller size than in wild-type mice

decreased motor neuron number ( J:206855 )

• motor neurons have almost totally disappeared by E18.5

motor neuron degeneration ( J:206855 )

• motor neurons have almost totally disappeared by E18.5

• however, neurotrophic factors enhance survival of motor neurons in culture

muscle

abnormal skeletal muscle morphology ( J:206855 )

• thin

decreased skeletal muscle fiber diameter ( J:206855 )

centrally nucleated skeletal muscle fibers ( J:206855 )

respiratory system

respiratory failure ( J:206855 )

behavior/neurological

abnormal posture ( J:206855 )

• abnormal body curvature at birth

homeostasis/metabolism

cyanosis ( J:206855 )

• at birth