Phenotypes for Apoe Ddit3 Tagln MGI:5781094 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
Ddit3^tm1.1Irt mutation (1 available); any Ddit3 mutation (20 available)
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:233223 )

• aortic root shows a approximate 30% reduction in lesion area and necrotic area compared to Apoe^tm1Unc Ddit3^tm1.1Irt double homozygotes, indicating decreased atherosclerotic plaque progression

• smooth muscle cell content is lower in aortic arch lesions compared to Ddit3^tm1.1Irt Apoe^tm1Unc double homozygotes

• mice on a Western diet show a lower content of alpha-actin-positive vascular smooth muscle cells in the lesions compared to Ddit3^tm1.1Irt Apoe^tm1Unc double homozygotes

• lesions show decreased vascular smooth muscle cell proliferation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:233223 )

N	• after 12 weeks of Western diet feeding, mice exhibit similar body weight, blood glucose, total plasma cholesterol, HDL cholesterol, plasma triglycerides, and blood pressure as Apoe^tm1Unc Ddit3^tm1.1Irt double homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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