Phenotypes Associated with This Genotype

Genotype
MGI:5780592

• Allelic Composition: Tg(Myh6*/tetO-Slc8a1)BJych/0; Tg(Myh6-tTA)55Rbns/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:151091 )

• sarcoplasmic reticulum Ca²⁺ content at 5.0 mM is higher than controls

abnormal cardiac muscle contractility ( J:151091 )

• increased contraction amplitude in response to elevation of Ca²⁺ as compared to controls

• at 0.6 mM [Ca²⁺] myocytes shorten less than controls

• at 5.0 mM [Ca²⁺] myocytes contract more than controls

• at 1.8 mM [Ca²⁺] contraction amplitudes are similar controls

• maximal shortening and relengthening velocities are both slower (at 0.6) and faster (at 5.0) than controls

• systolic and transient amplitudes are both lower (at 0.6) and higher (at 5.0) than controls, however, there is no difference in diastolic amplitude

abnormal myocardial fiber physiology ( J:151091 )

• increased I_NaCa (NCX1 current) in myocytes as voltage becomes more positive as compared to controls

muscle

abnormal myocardial fiber morphology ( J:151091 )

• sarcoplasmic reticulum Ca²⁺ content at 5.0 mM is higher than controls

abnormal cardiac muscle contractility ( J:151091 )

• increased contraction amplitude in response to elevation of Ca²⁺ as compared to controls

• at 0.6 mM [Ca²⁺] myocytes shorten less than controls

• at 5.0 mM [Ca²⁺] myocytes contract more than controls

• at 1.8 mM [Ca²⁺] contraction amplitudes are similar controls

• maximal shortening and relengthening velocities are both slower (at 0.6) and faster (at 5.0) than controls

• systolic and transient amplitudes are both lower (at 0.6) and higher (at 5.0) than controls, however, there is no difference in diastolic amplitude

nervous system

abnormal action potential ( J:151091 )

• action potential duration is prolonged at 50% and 90% repolarization as compared to controls