Phenotypes Associated with This Genotype

Genotype
MGI:5780418

• Allelic Composition: Tg(Camk2a-Grin2b)1Jzt/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced contextual conditioning behavior ( J:223086 )

• increased time spent freezing at 1 hour retention period

• increased time spent freezing at 1 day retention period

enhanced cued conditioning behavior ( J:223086 )

• increased time spent freezing at one day cued fear memory retention test as compared to wild-type

enhanced long-term object recognition memory ( J:223086 )

• enhanced long term recognition memory - increased time investigating novel object at 3 day retention test

fast extinction of fear memory ( J:223086 )

• more rapid fear extinction in contextual fear extinction paradigm and cued extinction learning as compared to wild-type

• mice exhibit decreased freezing response as early as second session (2 hours later) in contextual fear task and in subsequent exposures

• however, mice exhibit increased freezing 24 hours after training session as compared to wild-type