Phenotypes Associated with This Genotype

Genotype
MGI:5780307

• Allelic Composition: Tg(Camk2a-Grin2d/Grin2b)1Jzt/?
• Genetic Background: C57BL/6J-Tg(Camk2a-Grin2d/Grin2b)1Jzt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:223086 )

• decreased time spent freezing at one day cued fear memory retention test as compared to wild-type

impaired long-term object recognition memory ( J:223086 )

• impaired long term recognition memory - no preference for novel object (memory impairment/long term recognition memory) at 1 hour and 24 hour retention session

nervous system

enhanced long-term potentiation ( J:223086 )

• small increase in 5 Hz induced LTP in slices from the CA1 region of the hippocampus as compared to wild-type