Phenotypes Associated with This Genotype

Genotype
MGI:5780305

• Allelic Composition: Tg(Camk2a-Grin2b/Grin2a)1Jzt/?
• Genetic Background: C57BL/6J-Tg(Camk2a-Grin2b/Grin2a)1Jzt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:223086 )

• decreased time spent freezing at one day cued fear memory retention test as compared to wild-type

nervous system

enhanced long-term potentiation ( J:223086 )

• increase in 10 and 100 Hz induced LTP in slices from the CA1 region of the hippocampus as compared to wild-type

reduced long-term depression ( J:223086 )

• impaired LTD at 1 , 3 and 5 Hz in slices from the CA1 region of the hippocampus as compared to wild-type