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Phenotypes Associated with This Genotype
Genotype
MGI:5779970
Allelic
Composition		 Kdm6atm1.1Kaig/Y
Pax7tm2.1(cre/ERT2)Fan/Pax7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1.1Kaig mutation (1 available); any Kdm6a mutation (37 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle precursor cell morphology ( J:232700 )
• muscle progenitor cells fail to differentiate ex vitro
impaired skeletal muscle regeneration ( J:232700 )
• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice
• however, mice exhibit regeneration of smaller caliber myofibers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory