Phenotypes for Hras Tg(TPO-cre)1Shk MGI:5779651 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hras^tm1Jaf/? Tg(TPO-cre)1Shk/0
Genetic Background	involves: 129S6/SvEvTac * FVB/NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hras^tm1Jaf mutation (0 available); any Hras mutation (30 available)
Tg(TPO-cre)1Shk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:168249 )

N	• mice exhibit normal serum thyroid-stimulating hormone (TSH) and thyroxine (T4) levels

neoplasm

neoplasm ( J:168249 )

N	• mice treated with the goitrogen 6-propyl-2-thiouracil (PTU) for up to 20 weeks of age develop benign goiters and increases in TSH but do not develop thyroid cancer

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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