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Phenotypes Associated with This Genotype
Genotype
MGI:5779648
Allelic
Composition		 Braftm1Cpri/Braftm1Cpri
Gnastm3Lsw/Gnastm3Lsw
Tg(TPO-cre)1Shk/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Cpri mutation (0 available); any Braf mutation (61 available)
Gnastm3Lsw mutation (0 available); any Gnas mutation (53 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased thyroid tumor incidence ( J:168249 )
• mice develop smaller papillary thyroid tumors with greatly attenuated histological features resembling indolent papillary thyroid cancer in humans compared to single Braftm1Cpri conditional mutants

neoplasm
increased thyroid tumor incidence ( J:168249 )
• mice develop smaller papillary thyroid tumors with greatly attenuated histological features resembling indolent papillary thyroid cancer in humans compared to single Braftm1Cpri conditional mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory