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Phenotypes Associated with This Genotype
Genotype
MGI:5779645
Allelic
Composition
Braftm1Cpri/Braftm1Cpri
Tshrtm1Rmar/Tshrtm1Rmar
Tg(TPO-cre)1Shk/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Cpri mutation (0 available); any Braf mutation (61 available)
Tg(TPO-cre)1Shk mutation (1 available)
Tshrtm1Rmar mutation (1 available); any Tshr mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• architecture of thyroid follicles is disrupted at 3 weeks of age
• mice develop low-grade papillary thyroid cancer by 9 weeks of age, however, tumors are smaller and lack the characteristic tall cell features and are less invasive than in single Braftm1Cpri conditional mice

neoplasm
• mice develop low-grade papillary thyroid cancer by 9 weeks of age, however, tumors are smaller and lack the characteristic tall cell features and are less invasive than in single Braftm1Cpri conditional mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory