Phenotypes Associated with This Genotype

Genotype
MGI:5779552

• Allelic Composition: Tg(C9orf72*)450BLagi/?
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:232242 )

• mice exhibit a deficit in spatial learning which develops by 12 months and 18 months as determined by performance in Barnes maze

abnormal spatial working memory ( J:232242 )

• mice exhibit a deficit in spatial memory which develops by 12 months and 18 months as determined by performance in Barnes maze and radial arm maze

increased anxiety-related response ( J:232242 )

♂ • males exhibit anxiety as determined by marble burying test (18 months) and elevated plus maze (12 and 18 months)

nervous system

loss of hippocampal neurons ( J:232242 )

• age-dependent neuronal loss in dentate gyrus and CA1 region of hippocampus

• loss is repeat length dependent

neuronal cytoplasmic inclusions ( J:232242 )