Phenotypes Associated with This Genotype

Genotype
MGI:5776711

• Allelic Composition: Cldn18^{tm1(KOMP)Vlcg}/Cldn18^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac
• Cell Lines: 11015D-E7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

impaired lung alveolus development ( J:232069 )

• mice exhibit impaired alveolarization by 4 weeks of age but not at P3

abnormal pulmonary alveolar system morphology ( J:232069 )

• distal airspaces exhibit membrane ruffling and splaying at alveolar epithelial type 1 (AT1)-AT1 cell junctions

abnormal pulmonary alveolus epithelium morphology ( J:232069 )

• mice exhibit an alveolar epithelial permeability defect at 4, 12, and 16 weeks of age

• mice show a small, but significant, increase in bronchoalveolar lavage fluid podoplanin at P3 and a larger increase at 4 weeks, indicating alveolar epithelial cell injury in the lung after conversion to air breathing

increased type II pneumocyte number ( J:232069 )

• increase in alveolar epithelial type 2 (AT2) cells in the lungs by 4 weeks of age