Phenotypes Associated with This Genotype

Genotype
MGI:5776600

• Allelic Composition: Gorab^Gt(XG183)Byg/Gorab^Gt(XG183)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:231070 )

• mice die shortly after birth

integument

integument phenotype ( J:231070 )

N • epidermis architecture is normal

skin edema ( J:231070 )

underdeveloped hair follicles ( J:231070 )

• with fewer dermal condensate cells at E15.5 and E18.5

decreased hair follicle number ( J:231070 )

• at E18.5

abnormal dermal layer morphology ( J:231070 )

• at E15.5 and E18.5, dermal condensate cells exhibit impaired formation of primary cilia compared with wild-type cells

abnormal dermis papillary layer morphology ( J:231070 )

• at E18.5, the skin contains fewer dermal condensates or dermal papillae compared with wild-type mice

• however, dermal papilla cells are alkaline phosphatase positive

cellular

abnormal nonmotile primary cilium morphology ( J:231070 )

• at E15.5 and E18.5, dermal condensate cells exhibit impaired formation of primary cilia compared with wild-type cells

• however, mice exhibit normal primary cilia in keratinocyte and hair follicles

respiratory system

respiratory distress ( J:231070 )

• gasping for breath at birth

behavior/neurological

hunched posture ( J:231070 )

craniofacial

abnormal craniofacial morphology ( J:231070 )

homeostasis/metabolism

skin edema ( J:231070 )