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Phenotypes Associated with This Genotype
Genotype
MGI:5776501
Allelic
Composition
Tg(Plp)72Kan/Tg(Plp)72Kan
Genetic
Background
B6N.Cg-Tg(Plp)72Kan
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the optic tract shows some demyelination and contains numerous active microglia/macrophages
• in the chiasmal end of the optic tract, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles
• P60 mice exhibit thinner myelin sheaths
• proximal optic nerve shows numerous naked axons that appear normal with interspersed astrocytic processes
• the distal (chiasmal) end of the optic nerve is largely demyelinated and contains numerous active microglia/macrophages
• in the chiasmal end of the optic nerve, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles
• in the more distal portions of the P120 optic nerves, the numbers of CD45+ cells per optic nerve section are elevated more than 10-fold, however the completely demyelinated retinal portion shows no significant increase
• the optic nerve shows a rostral to caudal progression of active demyelination with microglial/macrophage activation and chronic hypomyelination due to dys- and demyelination with low-grade inflammation
• moderate dysmyelination
• the duration of the stimulus-evoked compound action potentials is longer in the optic nerve, indicating a decrease in conduction velocity
• mice exhibit impaired retrograde axonal transport in the optic nerve at sites associated with local inflammation and damaged myelin

vision/eye
• proximal optic nerve shows numerous naked axons that appear normal with interspersed astrocytic processes
• the distal (chiasmal) end of the optic nerve is largely demyelinated and contains numerous active microglia/macrophages
• in the chiasmal end of the optic nerve, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles
• in the more distal portions of the P120 optic nerves, the numbers of CD45+ cells per optic nerve section are elevated more than 10-fold, however the completely demyelinated retinal portion shows no significant increase

cellular
• in the chiasmal end of the optic tract, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Pelizaeus-Merzbacher disease DOID:3210 OMIM:312080
J:229229


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory