Phenotypes Associated with This Genotype

Genotype
MGI:5776487

• Allelic Composition: Fbxo41^{tm1(KOMP)Vlcg}/Fbxo41^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:222558 )

• mice do not survive beyond 10 weeks

postnatal lethality, incomplete penetrance ( J:222558 )

• most mice die before P14

nervous system

nervous system phenotype ( J:222558 )

N • young mice do not exhibit any signs of apoptosis or inflammation in the brain

abnormal neuronal migration ( J:222558 )

• delayed neuronal migration in the cerebellum

abnormal cerebellum external granule cell layer morphology ( J:222558 )

• thick in young cerebellum at P12

• mitotic PCNA+ cells in the residual external granule cell layer at P16

decreased brain weight ( J:222558 )

• severe at P16

abnormal cerebellar molecular layer ( J:222558 )

• increased number of cells

small cerebellum ( J:222558 )

behavior/neurological

limb grasping ( J:222558 )

tremors ( J:222558 )

ataxia ( J:222558 )

• severe

impaired balance ( J:222558 )

impaired coordination ( J:222558 )

abnormal gait ( J:222558 )

• dragging of the hind limbs

growth/size/body

decreased body weight ( J:222558 )

• severe at P16

postnatal growth retardation ( J:222558 )

• slight developmental delay at P5

cellular

abnormal neuronal migration ( J:222558 )

• delayed neuronal migration in the cerebellum