Phenotypes Associated with This Genotype

Genotype
MGI:5776478

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Sprr3^tm1.1Ppy/Sprr3^tm1.1Ppy
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:230470 )

N • endothelial cell survival and proliferation are normal

increased susceptibility to atherosclerosis ( J:230470 )

• 3-fold increase in lesion area in mice fed either normal chow or a high-fat diet compared to in Apoe^tm1Unc homozygotes

• increased susceptibility is not attributable to bone-marrow derived cells as determined by transplant experiments

vascular smooth muscle hypoplasia ( J:230470 )

• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice

• however, disease-free arteries exhibit normal VSMC content

abnormal vascular smooth muscle physiology ( J:230470 )

• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice

• vascular smooth muscle cells exhibit increased cellular sensitivity to hydrogen peroxide compared with control cells

• however, disease-free arteries exhibit normal VSMC apoptosis rates

cellular

increased cellular sensitivity to hydrogen peroxide ( J:230470 )

• in vascular smooth muscle cells

muscle

vascular smooth muscle hypoplasia ( J:230470 )

• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice

• however, disease-free arteries exhibit normal VSMC content

abnormal vascular smooth muscle physiology ( J:230470 )

• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice

• vascular smooth muscle cells exhibit increased cellular sensitivity to hydrogen peroxide compared with control cells

• however, disease-free arteries exhibit normal VSMC apoptosis rates