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Phenotypes Associated with This Genotype
involves: C57BL/6 * DBA/2
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phenotype observed in females
phenotype observed in males
N normal phenotype
• mice display a continued high activity and failure to habituate to a novel environment
• during the hidden portion of the water maze, mutants require a longer distance and time to find the platform compared to controls
• however, during the cued portion of the water maze, mutants perform similarly to controls
• on day 7, during the probe portion of the water maze, mice show impairments in memory retention
• 6-8 and 12-14 month old mice, but not 3-4 month old mice, show impairments when crossing a round beam, with a higher rate of errors
• increase in total activity beginning at 3-4 months of age with a time dependent increase 6-8 and 12-14 months of age

nervous system
• 8-10 month old mice show alterations in the mitochondria of the hippocampus dentate gyrus, with some enlarged and elongated mitochondria that display disorganized cresta
• decrease in the neocortical volume
• age dependent increase in tau protein aggregation in layer II-III and V pyramidal neurons in the neocortex and pyramidal and granular cells in the hippocampus
• tau accumulates in synaptohysin positive presynaptic terminals and in MAP2 immunoreactive dendrites
• dendrites show accumulation of lamellar bodies and straight filamentous structures
• reduction in the number of neurons in the CA1 and dentate gyrus of the hippocampus
• intra-neuronal inclusions in the frontal cortex
• increase in GFAP immunoreactivity in the neocortex and hippocampus and glial cells are detected in the hippocampus indicating neurodegeneration
• axonal dystrophy in 8-10 month old mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Pick's disease DOID:11870 OMIM:172700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory