Phenotypes Associated with This Genotype

Genotype
MGI:5774772

• Allelic Composition: Ccr5^tm1(CCR5)Pfi/Ccr5^tm1(CCR5)Pfi
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:227458 )

N • mice develop a similar severity of pulmonary hypertension as wild-type mice after 18 days of hypoxia

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:227458 )

• treatment with Maraviroc 200 attenuates but does not fully abrogate hypoxia-induced pulmonary hypertension development in mutants compared to having no effect in wild-type mice