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Phenotypes Associated with This Genotype
Genotype
MGI:5774687
Allelic
Composition
Gabra1tm1.1Mjga/Gabra1+
Genetic
Background
B6J.Cg-Gabra1tm1.1Mjga
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra1tm1.1Mjga mutation (0 available); any Gabra1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice at P120 exhibit a discharge that starts with two or more consecutive spikes and/or waves and occurs with an irregular periodicity and a high frequency, features resembling polyspike-and-wave discharges
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
• spontaneous polyspike-and-wave discharges are more frequent at P120 than P35
• seizures in P120 mutants occur with a higher probability at shorter latencies after PTZ injection than in wild-type mice
• 10% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
• one spontaneous generalized tonic-clonic seizure was recorded in one P120 mouse
• mice exhibit absence-like seizures at P35 and P120
• mice exhibit abundant spike-wave discharges (SWDs) at P35 and P120
• each SWD consists of very rhythmic, 6-8 Hz spikes, positive transients, and waves
• SWDs are associated with behavioral arrest

muscle
• 10% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs

nervous system
• mice at P120 exhibit a discharge that starts with two or more consecutive spikes and/or waves and occurs with an irregular periodicity and a high frequency, features resembling polyspike-and-wave discharges
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
• spontaneous polyspike-and-wave discharges are more frequent at P120 than P35
• seizures in P120 mutants occur with a higher probability at shorter latencies after PTZ injection than in wild-type mice
• 10% of polyspike-and-wave discharges are associated with visible myoclonic jerks
• spontaneous polyspike-and-wave discharges and myoclonic seizures are very infrequent compared with the SWDs
• one spontaneous generalized tonic-clonic seizure was recorded in one P120 mouse
• mice exhibit absence-like seizures at P35 and P120
• mice exhibit abundant spike-wave discharges (SWDs) at P35 and P120
• each SWD consists of very rhythmic, 6-8 Hz spikes, positive transients, and waves
• SWDs are associated with behavioral arrest
• reduction in mIPSC amplitudes and increase in the time course of current decay in P35 and P120 cortices

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
idiopathic generalized epilepsy DOID:1827 OMIM:600669
J:227437


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory