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Phenotypes Associated with This Genotype
Genotype
MGI:5774475
Allelic
Composition		 Gata4tm1(cre)Svs/Gata4+
Tg(Sox3-GFP,Tyr)HolNpln/Tg(Sox3-GFP,Tyr)HolNpln
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1(cre)Svs mutation (0 available); any Gata4 mutation (36 available)
Tg(Sox3-GFP,Tyr)HolNpln mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system

cellular
abnormal enteric neural crest cell migration ( J:229828 )
• colonic aganglionosis is caused by a cell-autonomous defect in enteric neural crest cell migration

embryo
abnormal enteric neural crest cell migration ( J:229828 )
• colonic aganglionosis is caused by a cell-autonomous defect in enteric neural crest cell migration

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory