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Phenotypes Associated with This Genotype
Genotype
MGI:5774471
Allelic
Composition
Cdx1tm1Pgr/Cdx1tm1Pgr
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(Pax3-cre)1Joe/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(Pax3-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants

embryo
• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants

integument
• increase in penetrance and extent of white spotting in the posterior regions

nervous system
• E10.5 mutants exhibit abnormalities of the hypoglossal nerve, with the converging roots appearing disorganized and less dense and resulting in a reduced number of elongating axons that are shorter
• E10.5 embryos exhibit the presence of fusions of dorsal root ganglia in the cervical region

pigmentation
• increase in penetrance and extent of white spotting in the posterior regions


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory