Phenotypes Associated with This Genotype

Genotype
MGI:5774469

• Allelic Composition: Gt(ROSA)26Sor^{tm1(en/Cdx1,-EGFP)Npln}/Gt(ROSA)26Sor⁺; Tg(T-cre)1Lwd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

rib fusion ( J:231654 )

• 33% of mutants show fusion of ribs in the thoracic region

abnormal vertebrae morphology ( J:231654 )

• neonates show vertebral malformations with a higher penetrance at the cervical level than at thoracic and lumber regions

decreased thoracic vertebrae number ( J:231654 )

• reduction in the number of thoracic vertebrae (12 instead of 13)

abnormal cervical vertebrae morphology ( J:231654 )

• absence of the tuberculum anterior on C6

decreased lumbar vertebrae number ( J:231654 )

• some mutants only have five lumbar vertebrae instead of six

abnormal vertebral arch morphology ( J:231654 )

• cervical regions show malformed neural arches

vertebral fusion ( J:231654 )

• neonates show vertebral fusions with a higher penetrance at the cervical level than at thoracic and lumber regions

• cervical vertebra 1 and associated anterior arch of the atlas are fused to the basioccipital bone

vertebral transformation ( J:231654 )

• neonates show the presence of a high number of homeotic transformations

• C2/C3 are anteriorly transformed

cervical vertebral transformation ( J:231654 )

• cervical regions show anterior homeotic transformations