Phenotypes Associated with This Genotype

Genotype
MGI:5770649

• Allelic Composition: Ciz1^{Gt(IST13830B6)Tigm}/Ciz1^{Gt(IST13830B6)Tigm}
• Genetic Background: B6J.B6N-Ciz1^{Gt(IST13830B6)Tigm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased aggression towards mice ( J:231433 )

♂ • in male, but not female, mice in a tube dominance test

impaired coordination ( J:231433 )

♀ • female mice exhibit shorter latency to fall off a rotarod and more slips on a 9 mm square or round beams

short stride length ( J:231433 )

♀ • with higher stride frequency and smaller hind paw area in female mice

decreased vertical activity ( J:231433 )

• in female and male mice

decreased locomotor activity ( J:231433 )

♀ • in female mice

hyperactivity ( J:231433 )

♂ • in male mice

immune system

increased neutrophil cell number ( J:231433 )

• trend

increased monocyte cell number ( J:231433 )

• trend

growth/size/body

decreased body size ( J:231433 )

• at 3 months, without evidence of progressive weight loss up to 10 months

hematopoietic system

increased neutrophil cell number ( J:231433 )

• trend

increased monocyte cell number ( J:231433 )

• trend