Phenotypes Associated with This Genotype

Genotype
MGI:5770635

• Allelic Composition: Hsd17b1^{tm1(KOMP)Vlcg}/Hsd17b1^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:225533 )

♀N • female mice exhibit normal estrous cycle and ovulation

abnormal ovary morphology ( J:225533 )

♀ • large granular cell bundles of Sertoli-like cells in the stroma

♀ • however, follicles at all stages are normal

abnormal corpus luteum morphology ( J:225533 )

♀ • less define basement membrane of corpus luteum than in wild-type mice

decreased corpora lutea number ( J:225533 )

♀

increased ovary weight ( J:225533 )

♀ • during estrus and pseudopregnancy

abnormal uterus weight ( J:225533 )

♀ • uterus weight fails to increase during proestrus unlike in wild-type mice

delayed vaginal opening ( J:225533 )

♀ • in some mice

♀ • however, overall the opening day is not significantly different

reduced female fertility ( J:225533 )

♀ • female mice produce 6 litters with 32 pups compared to 23 litters with 232 pups for wild-type female mice

decreased litter size ( J:225533 )

♀ • female mice produce 6 litters with 32 pups compared to 23 litters with 232 pups for wild-type female mice

homeostasis/metabolism

increased luteinizing hormone level ( J:225533 )

♀ • 5-fold at estrus stage

abnormal progesterone level ( J:225533 )

♀ • decreased concentration in the ovaries at estrus and during pseudopregnancy

endocrine/exocrine glands

abnormal ovary morphology ( J:225533 )

♀ • large granular cell bundles of Sertoli-like cells in the stroma

♀ • however, follicles at all stages are normal

abnormal corpus luteum morphology ( J:225533 )

♀ • less define basement membrane of corpus luteum than in wild-type mice

decreased corpora lutea number ( J:225533 )

♀

increased ovary weight ( J:225533 )

♀ • during estrus and pseudopregnancy

growth/size/body

increased ovary weight ( J:225533 )

♀ • during estrus and pseudopregnancy