Phenotypes Associated with This Genotype

Genotype
MGI:5770598

• Allelic Composition: Runx2^tm1Hkiy/Runx2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Runx2^tm1Hkiy/Runx2⁺ and Runx2^tm1Hkiy/Runx2^tm1Hkiy mice show delayed bone ossification

skeleton

impaired osteoblast differentiation ( J:223410 )

• in vitro, E18.5 calvarial cells cultured osteogenic medium show an intermediate defect in osteoblast development, as determined by bone nodule formation and alkaline phosphatase activity

small clavicle ( J:223410 )

• at E18.5

delayed endochondral bone ossification ( J:223410 )

• reduced ossification of hyoid bone at E18.5

• however, the volume and other quantified bone mineral parameters of femurs are not statistically altered

delayed intramembranous bone ossification ( J:223410 )

• at E18.5, delay in the formation of calvaria is intermediate between that of wild-type and homozygous mutant mice

cellular

impaired osteoblast differentiation ( J:223410 )

• in vitro, E18.5 calvarial cells cultured osteogenic medium show an intermediate defect in osteoblast development, as determined by bone nodule formation and alkaline phosphatase activity