Phenotypes Associated with This Genotype

Genotype
MGI:5770441

• Allelic Composition: Tg(RasE)290Biat/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenocarcinoma incidence ( J:226601 )

• mice inhaling adenoviral particles expressing cre recombinase (AdCre) develop pan-cytokeratin-positive lung adenocarcinomas; about 85% of tumors show simultaneous activation of the three alleles

• lung tumors expressing all three alleles are slightly bigger than tumors not expressing all three alleles

• substantial percentage of triple allele activated tumors are invasive while non-triple allele activated tumors are noninvasive

• mice inhaling AdCre particles do not develop pancreatic or skin-appendage tumors

respiratory system

increased lung adenocarcinoma incidence ( J:226601 )

• mice inhaling adenoviral particles expressing cre recombinase (AdCre) develop pan-cytokeratin-positive lung adenocarcinomas; about 85% of tumors show simultaneous activation of the three alleles

• lung tumors expressing all three alleles are slightly bigger than tumors not expressing all three alleles

• substantial percentage of triple allele activated tumors are invasive while non-triple allele activated tumors are noninvasive

• mice inhaling AdCre particles do not develop pancreatic or skin-appendage tumors