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Phenotypes Associated with This Genotype
Genotype
MGI:5770303
Allelic
Composition		 Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background		 involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (48 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (2 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:222944 )
• mice exhibit accelerated onset and succumb to complete hindlimb paralysis faster than control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory