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Phenotypes Associated with This Genotype
Genotype
MGI:5770244
Allelic
Composition
Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brinp1tm1.1Pib mutation (0 available); any Brinp1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most pups are found dead 12-48 hours after birth
• only 22% of pups survive longer than 3 days

growth/size/body
• 10% reduction in adult body weight
• however, mice have normal body length and brain size and embryo size is normal
• impaired postnatal growth
• mice show a delay in weight gain from week 3 until adulthood

behavior/neurological
N
• mice show normal auditory, visual and olfactory capabilities, normal motor coordination on the rotarod and no depressive-like behaviors
• mice show normal preference for investigating an unfamiliar object in a novel object recognition test, no abnormalities in startle response or sensory gating
• males spend slightly less time investigating the empty cages than wild-type mice, which may indicate altered exploratory behavior
• mice spend more time in the locomotor cell
• males spend less time in a closed arm of the elevated plus maze than controls
• however, the number of entries into each arm of the elevated plus maze is unaffected
• in the Y-maze test, mice do not show the typical increase in time spent exploring a novel arm, indicating impaired short-term memory
• however, mice show normal long-term memory in the Morris water maze
• little or no milk is present in the stomach of dead mutants
• females, but not males, show decreased grooming
• mice show increased rearing in the locomoter cell and in a sawdust-lined, plexiglass box
• mice show hyperactivity during both trials of the three-chamber social interaction test
• in the locomotor cell, mice travel 50% further, spend less time resting, and show a consistent increase in velocity
• males show faster time and shorter swim distances in the Morris water maze, most likely due to their hyperactivity
• treatment with methylphenidate, a psychostimulant drug, does not decrease hyperactivity in mutants
• mice show an increase in stereotypic episodes
• mice spend less time interacting with the intruder mouse in the second trial of the three-chamber social interaction test, while showing no difference in interaction time with the empty cage
• males presented with pheromones from estrus or proestrous females show a trend towards reduced number of calls, a longer latency to call and longer latency to investigate the cotton bud, and increased peak frequency of calls
• mice exhibit altered ultrasonic vocalization, showing shorter call durations, emitting a higher percentage of short calls and lower percentage of complex or composite longer calls

nervous system
• mice show an increase in PV-positive interneurons in the somatosensory cortex
• increase in total PV-positive cells in the hippocampus
• increase in cellularity of layers IV and VI of the neocortex
• however, cortical cell survival and proliferation is normal at E18.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory