Phenotypes Associated with This Genotype

Genotype
MGI:5769985

• Allelic Composition: Akt1s1^tm1.1Rrth/Akt1s1^tm1.1Rrth
• Genetic Background: B6(Cg)-Akt1s1^tm1.1Rrth

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to ischemic brain injury ( J:231219 )

• a model of focal ischemia induced by middle cerebral artery (MCA) suture occlusion for 60 min, mice exhibit increased infarction size and with worsened neurological scores compared with wild-type mice

increased cerebral infarct size ( J:231219 )

• with worsened neurological scores in a model of focal ischemia induced by middle cerebral artery (MCA) suture occlusion for 60 min

• in another model induced by permanent occlusion of both the distal MCA and ipsilateral common carotid artery

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:231219 )

• a model of focal ischemia induced by middle cerebral artery (MCA) suture occlusion for 60 min, mice exhibit increased infarction size and with worsened neurological scores compared with wild-type mice

increased cerebral infarct size ( J:231219 )

• with worsened neurological scores in a model of focal ischemia induced by middle cerebral artery (MCA) suture occlusion for 60 min

• in another model induced by permanent occlusion of both the distal MCA and ipsilateral common carotid artery