Phenotypes Associated with This Genotype

Genotype
MGI:5767756

• Allelic Composition: Pgap2^{tm1b(EUCOMM)Wtsi}/Pgap2^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pgap2^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0543_5_G04

Data Sources

IMPC Data for Pgap2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta morphology ( J:261316 )

• branching morphology defect

• fibrotic/acellular lesions

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

abnormal visceral yolk sac morphology ( J:261316 )

• yolk sac abnormalities

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI