Phenotypes Associated with This Genotype

Genotype
MGI:5767633

• Allelic Composition: Dhx35^{tm1b(EUCOMM)Wtsi}/Dhx35^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Dhx35^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0546_4_C06

Data Sources

IMPC Data for Dhx35

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

double lumen aortic arch ( J:239583 )

DMDD

right aortic arch ( J:239583 )

DMDD

retroesophageal left subclavian artery ( J:239583 )

DMDD

abnormal vertebral artery origin ( J:239583 )

DMDD

abnormal basilar artery morphology ( J:239583 )

DMDD

symmetric azygos veins ( J:239583 )

DMDD

common truncal valve ( J:239583 )

DMDD

persistent truncus arteriosus ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

craniofacial

basisphenoid bone foramen ( J:239583 )

DMDD

short snout ( J:239583 )

DMDD

embryo

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

endocrine/exocrine glands

abnormal adenohypophysis morphology ( J:239583 )

DMDD

absent mammary gland ( J:239583 )

DMDD

growth/size/body

short snout ( J:239583 )

DMDD

thoracoschisis ( J:239583 )

DMDD

immune system

absent connection between subcutaneous lymph vessels and lymph sac ( J:239583 )

DMDD

integument

absent mammary gland ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• fewer than the expected number of fetuses are seen at E14.5, indicating sub-viability at this time

nervous system

abnormal basilar artery morphology ( J:239583 )

DMDD

abnormal adenohypophysis morphology ( J:239583 )

DMDD

holoprosencephaly ( J:239583 )

DMDD

abnormal brain internal capsule morphology ( J:239583 )

DMDD

absent olfactory bulb ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

skeleton

basisphenoid bone foramen ( J:239583 )

DMDD

scoliosis ( J:239583 )

DMDD

abnormal vertebrae morphology ( J:239583 )

DMDD

vision/eye

abnormal optic cup morphology ( J:239583 )

DMDD