Phenotypes Associated with This Genotype

Genotype
MGI:5760031

• Allelic Composition: Ddr1^tm1Lex/Ddr1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:82809 )

• homozygous mutant mice exhibited decreased anxiety-related response in the open field compared with their wild-type littermates and the historical mean

increased locomotor activity ( J:82809 )

• homozygous mutant mice exhibited increased locomotor activity

cardiovascular system

abnormal aorta collagen fibril morphology ( J:234902 )

• greater adventitial collagen layer compared with wild-type mice

• larger and sometimes irregular cross-sections of collagen fibrils

• higher average depth of D-period and higher mean D-depth per fibril

• however, the D-period length per fibrils is normal