Phenotypes Associated with This Genotype

Genotype
MGI:5758951

• Allelic Composition: Tg(BEST1-HTRA1)44Ybf/0
• Genetic Background: involves: C57BL/6 * CBA * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal retina pigment epithelium morphology ( J:230011 )

• 15.3% of mice with PCV show hemorrhagic and serous pigment epithelial detachment in the lesion area

• males show more severe pigment epithelial detachment than females

• retinal pigment epithelium degeneration

vision/eye

abnormal retina pigment epithelium morphology ( J:230011 )

• 15.3% of mice with PCV show hemorrhagic and serous pigment epithelial detachment in the lesion area

• males show more severe pigment epithelial detachment than females

• retinal pigment epithelium degeneration

abnormal optic choroid morphology ( J:230011 )

• 94.7% of mice show features of polypoidal choroidal vasculopathy (PCV), including branching vascular network and terminal polypoidal dilations (polyps), with age of onset between 4 and 5 weeks

• single polyp is the most common PCV lesion (100%), followed by string (63.7%) and cluster (51.6%) polyps

• 34.7% of mice with PCV exhibit late geographic hyperfluorescence and polyps are frequently seen in these areas

• 11.3% of mice show hyperfluorescent plaque

• males show more severe phenotypes such as late geographic hyperfluorescence and pigment epithelial detachment than females

• lesion numbers per eye increase over time