Phenotypes Associated with This Genotype

Genotype
MGI:5757476

• Allelic Composition: Parp1^{tm1b(EUCOMM)Hmgu}/Parp1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Parp1^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0555_6_C04

Data Sources

IMPC Data for Parp1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - ICS

hematopoietic system

decreased NK cell number ( J:211773 )

IMPC - ICS

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - ICS

immune system

immune system phenotype ( J:211773 )

IMPC - ICS

decreased NK cell number ( J:211773 )

IMPC - ICS

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - ICS

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - ICS

nervous system

increased prepulse inhibition ( J:211773 )

IMPC - ICS

vision/eye

abnormal retina inner nuclear layer morphology ( J:211773 )

♀

IMPC - ICS

decreased total retina thickness ( J:211773 )

IMPC - ICS