Phenotypes Associated with This Genotype

Genotype
MGI:5757173

• Allelic Composition: Gh^{tm1.1(KOMP)Vlcg}/Gh^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Gh^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 10368A-F1

Data Sources

IMPC Data for Gh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - UCD

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - UCD

decreased locomotor activity ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - UCD

small heart ( J:211773 )

IMPC - UCD

decreased heart weight ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

decreased thymus weight ( J:211773 )

♂

IMPC - UCD

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - UCD

decreased body length ( J:211773 )

IMPC - UCD

hematopoietic system

decreased thymus weight ( J:211773 )

♂

IMPC - UCD

thrombocytopenia ( J:211773 )

♂

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

small spleen ( J:211773 )

IMPC - UCD

decreased spleen weight ( J:211773 )

♂

IMPC - UCD

homeostasis/metabolism

decreased fasting circulating glucose level ( J:211773 )

♀

IMPC - UCD

impaired glucose tolerance ( J:211773 )

IMPC - UCD

immune system

decreased thymus weight ( J:211773 )

♂

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

small spleen ( J:211773 )

IMPC - UCD

decreased spleen weight ( J:211773 )

♂

IMPC - UCD

liver/biliary system

decreased liver weight ( J:211773 )

♂

IMPC - UCD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

nervous system

decreased brain weight ( J:211773 )

♂

IMPC - UCD

decreased prepulse inhibition ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - UCD

small kidney ( J:211773 )

IMPC - UCD

decreased kidney weight ( J:211773 )

♂

IMPC - UCD

reproductive system

female infertility ( J:211773 )

♀

IMPC - UCD

male infertility ( J:211773 )

♂

IMPC - UCD

respiratory system

decreased lung weight ( J:211773 )

♂

IMPC - UCD

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - UCD

decreased bone mineral content ( J:211773 )

IMPC - UCD

decreased bone mineral density ( J:211773 )

IMPC - UCD