About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5755868
Allelic
Composition		 Col1a1tm17(tetO-GFP,-cas9*)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm17(tetO-GFP,-cas9*)Slowe mutation (0 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (32 available); any Gt(ROSA)26Sor mutation (1062 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
ectopic Paneth cells ( J:222595 )
• increased in doxycycline-treated mice
abnormal small intestinal crypt cell physiology ( J:222595 )
• doxycycline-treated mice exhibit dramatic hyper-proliferation and crypt expansion, blocked differentiation and ectopic Paneth cell production compared with control mice
abnormal small intestinal crypt cell proliferation ( J:222595 )
• increased in doxycycline-treated mice

endocrine/exocrine glands
ectopic Paneth cells ( J:222595 )
• increased in doxycycline-treated mice

cellular
abnormal small intestinal crypt cell proliferation ( J:222595 )
• increased in doxycycline-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory