Phenotypes Associated with This Genotype

Genotype
MGI:5755485

• Allelic Composition: Brd7^tm1.2Ligy/Brd7^tm1.2Ligy
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:223952 )

N • mice exhibit normal anxiety and depression behaviors in an open field, light-dark box or forced swim test

abnormal long-term object recognition memory ( J:223952 )

• decreased discrimination ratio

impaired short-term object recognition memory ( J:223952 )

• decreased discrimination ratio

impaired spatial learning ( J:223952 )

• increased latency to reach the platform during training and latency to cross the platform on the test day in a Morris water maze test

• mice exhibit reduced entries in the platform zone on test day in a Morris water maze test compared with wild-type mice

• mice spend less time in the new arm of a Y-maze compared with wild-type mice

• however, number of entries in a Y-maze is normal

abnormal social/conspecific interaction behavior ( J:223952 )

• mice spend less time in the social target side compared with wild-type mice

nervous system

nervous system phenotype ( J:223952 )

N • mice exhibit normal neuron survival

abnormal dendrite morphology ( J:223952 )

• reduced apical dendritic branching, basal dendritic branching and basal dendritic spines in the medial prefrontal cortex

• however, mice exhibit normal apical dendritic branching, basal dendritic branching, apical dendrite spines and basal dendrite spines in the hippocampus