Analysis Tools
digestive/alimentary system
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• periodontium shows detachment of the junctional epithelium in 12 and 24 week old mice
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skeleton
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• the interdental region between the first and second mandibular molars shows bone loss at 12 weeks of age and by 24 weeks of age, very little alveolar bone remains in the interdental region
• at 24 weeks of age, the alveolar bone in the furcation region becomes island-like (bone spicules)
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• at 4 weeks of age, collagen fibers in the periodontal ligament are thinner and more disorganized and some collagen fibers appear broken or detached from the alveolar bone or root surface
• inflammation is seen in the periodontal ligament of 12 and 24 week old mice
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• by 24 weeks of age, certain areas of the periodontal ligament are necrotized, accompanied by formation of abscesses due to bone absorption
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• amounts of cellular cementum appear to be reduced in 4, 12 and 24 week old mice
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• by 24 weeks of age, certain areas of the periodontal ligament are necrotized, accompanied by formation of abscesses due to bone absorption
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• alveolar bone in the furcation and interdental regions shows a lower mineral density at 4 weeks of age, it appears more porous at 12 weeks of age, and abnormalities worsen with age, with 24 week old mice showing severe defects and porosities in the alveolar bone
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• reduction in alveolar bone volume at 12 and 24 week of age
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• at 4 weeks of age, the lacuno-canalicular networks in alveolar bone appear disorganized
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• lacunae of osteocytes in the alveolar bone of the interdental or furcation regions appear larger and are irregularly distributed with fewer organized canaliculi
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• osteocytes processes in the alveolar bone appear abnormal
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• fewer organized canaliculi are observed in alveolar bone; canaliculi appear thicker and more randomly distributed
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• the lacunae of osteocytes appeared "collapsed"
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immune system
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• inflammation in the dental pulp
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• mice develop periodontal disease, showing increased inflammation in the interdental and furcation regions
• inflammation is seen in the periodontal ligament of 12 and 24 week old mice
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craniofacial
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• the interdental region between the first and second mandibular molars shows bone loss at 12 weeks of age and by 24 weeks of age, very little alveolar bone remains in the interdental region
• at 24 weeks of age, the alveolar bone in the furcation region becomes island-like (bone spicules)
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• at 4 weeks of age, collagen fibers in the periodontal ligament are thinner and more disorganized and some collagen fibers appear broken or detached from the alveolar bone or root surface
• inflammation is seen in the periodontal ligament of 12 and 24 week old mice
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• by 24 weeks of age, certain areas of the periodontal ligament are necrotized, accompanied by formation of abscesses due to bone absorption
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• amounts of cellular cementum appear to be reduced in 4, 12 and 24 week old mice
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• by 24 weeks of age, certain areas of the periodontal ligament are necrotized, accompanied by formation of abscesses due to bone absorption
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• periodontium shows detachment of the junctional epithelium in 12 and 24 week old mice
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• 12 and 24 week old mice show formation of periodontal pockets
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growth/size/body
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• the interdental region between the first and second mandibular molars shows bone loss at 12 weeks of age and by 24 weeks of age, very little alveolar bone remains in the interdental region
• at 24 weeks of age, the alveolar bone in the furcation region becomes island-like (bone spicules)
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• at 4 weeks of age, collagen fibers in the periodontal ligament are thinner and more disorganized and some collagen fibers appear broken or detached from the alveolar bone or root surface
• inflammation is seen in the periodontal ligament of 12 and 24 week old mice
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• by 24 weeks of age, certain areas of the periodontal ligament are necrotized, accompanied by formation of abscesses due to bone absorption
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• amounts of cellular cementum appear to be reduced in 4, 12 and 24 week old mice
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• by 24 weeks of age, certain areas of the periodontal ligament are necrotized, accompanied by formation of abscesses due to bone absorption
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• periodontium shows detachment of the junctional epithelium in 12 and 24 week old mice
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• 12 and 24 week old mice show formation of periodontal pockets
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• small stature
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homeostasis/metabolism
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• about 50% reduction in serum phosphorus levels
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• the majority of collagen fibers in the interdental area are lost in 12 week old mice and nearly all of the collagen fibers in the interdental region are broken down at 24 weeks of age
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cellular
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• by 24 weeks of age, certain areas of the periodontal ligament are necrotized, accompanied by formation of abscesses due to bone absorption
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