Phenotypes Associated with This Genotype

Genotype
MGI:5755094

• Allelic Composition: Nras^tm1Tyj/Nras^tm1Tyj; Tg(Tyr-cre/ERT2)1Lru/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal skin morphology ( J:198244 )

• mice painted with tamoxifen on to shaven back skin develop large multicellular nevi in the deep dermal and periadnexal regions of the skin

pigmentation

hyperpigmentation ( J:198244 )

• mice painted with tamoxifen on to shaven back skin at about 2 months of age exhibit darkening of the skin within 4 to 8 months; darkening is more apparent in tamoxifen-treated areas but systemic effects are seen with darkening of the tails

neoplasm

neoplasm ( J:198244 )

N • tamoxifen painted mice do not develop cutaneous melanoma, even after 24 months of tamoxifen-induced expression