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Phenotypes Associated with This Genotype
Genotype
MGI:5755043
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increased open to total arm entry ratio in 5 month old females, however, phenotype is more severe in homozygotes
• increased clasping during tail suspension in 5 month old females as compared to controls, however clasping in homozygotes is more severe

growth/size/body
• reduced body weight at 2 months old females, but weight is similar to control by 5 months of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory