Phenotypes Associated with This Genotype

Genotype
MGI:5754726

• Allelic Composition: Tg(ACTB-Edn1)1398Clou/0; E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

temporal bone squamous part hypoplasia ( J:221133 )

• hypoplastic squamosal bone

abnormal mandibular angle morphology ( J:221133 )

• duplication of the angular process

absent mandibular coronoid process ( J:221133 )

• the coronoid process of the mandible is lost due to fusion of the mandible and the duplicated mandible

upper jaw to lower jaw transformation ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

palatine bone hypoplasia ( J:221133 )

abnormal zygomatic bone morphology ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

ectopic cranial bone ( J:221133 )

• an ectopic bone is present suggestive of duplicated gonial bone and/or part of the tympanic ring

abnormal incus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

abnormal malleus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

gonial bone hypoplasia ( J:221133 )

cleft palate ( J:221133 )

digestive/alimentary system

palatine bone hypoplasia ( J:221133 )

cleft palate ( J:221133 )

growth/size/body

palatine bone hypoplasia ( J:221133 )

cleft palate ( J:221133 )

hearing/vestibular/ear

abnormal incus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

abnormal malleus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

gonial bone hypoplasia ( J:221133 )

tympanic ring hypoplasia ( J:221133 )

• hypoplastic tympanic ring

skeleton

temporal bone squamous part hypoplasia ( J:221133 )

• hypoplastic squamosal bone

abnormal mandibular angle morphology ( J:221133 )

• duplication of the angular process

absent mandibular coronoid process ( J:221133 )

• the coronoid process of the mandible is lost due to fusion of the mandible and the duplicated mandible

upper jaw to lower jaw transformation ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

palatine bone hypoplasia ( J:221133 )

abnormal zygomatic bone morphology ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

ectopic cranial bone ( J:221133 )

• an ectopic bone is present suggestive of duplicated gonial bone and/or part of the tympanic ring

abnormal incus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

abnormal malleus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

gonial bone hypoplasia ( J:221133 )