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Phenotypes Associated with This Genotype
Genotype
MGI:5752850
Allelic
Composition
Sh3tc2m1J/Sh3tc2m1J
Genetic
Background
B6.Cg-Sh3tc2m1J/GrsrRwb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh3tc2m1J mutation (1 available); any Sh3tc2 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system
• conduction block intermediate between wildtype and that found in mice additionally homozygous for a Nrcam null allele

nervous system
N
• no abnormalities found in the neuromuscular junctions of the plantaris muscle
• supernumerary Schwann cell processes in peripheral motor and sensory nerves (J:229591)
• supernumerary Schwann cell processes in the adult but no decrease in myelinated axon number or axon diameter (J:240096)
• thin myelin sheath observed in peripheral motor and sensory nerves are due to a reduced number of myelin wraps and not changes in myelin packing (J:229591)
• reduced myelin thickness of the femoral nerve in adults (J:240096)
• mice exhibit reduced nerve conduction velocities by 3 months of age (J:229591)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory