Phenotypes Associated with This Genotype

Genotype
MGI:5752161

• Allelic Composition: Tg(IghH280)48Dvs/?
• Genetic Background: NOD/ShiLtDvs-Tg(IghH280)48Dvs/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

insulitis ( J:274578 )

• mice develop insulitis earlier than NOD/ShiLtDvs controls

immune system

insulitis ( J:274578 )

• mice develop insulitis earlier than NOD/ShiLtDvs controls

increased susceptibility to autoimmune diabetes ( J:274578 )

• 90-95% of mice develop type 1 diabetes by 20 weeks of age

• onset is accelerated as compared to NOD/ShiLtDvs controls (80-90% by 30-40 weeks of age)