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Phenotypes Associated with This Genotype
Genotype
MGI:5751863
Allelic
Composition
Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr/0
Tg(tetO-FMR1*,-EGFP)#Rkhu/0
Genetic
Background
involves: C57BL/6JRj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Hnrnpa2b1-rtTA2S*M2)9Jstr mutation (1 available)
Tg(tetO-FMR1*,-EGFP)#Rkhu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice treated with doxycycline (dox) starting at 3 weeks of age begin to lose weight after 2 days of dox treatment

liver/biliary system
• marker analysis indicates mitochondrial dysfunction in the liver of dox treated mice
• mice treated with dox exhibit mild liver steatosis
• livers are pale and pink in mice treated with dox

mortality/aging
• mice treated with dox starting at 3 weeks of age die after 5 days of dox treatment

nervous system
N
• ubiquitin positive inclusions are not seen in mice treated with dox for 4 days

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fragile X-associated tremor/ataxia syndrome DOID:0050879 OMIM:300623
J:229379


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory