Phenotypes Associated with This Genotype

Genotype
MGI:5751748

• Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk; Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

increased mesenchymal cell proliferation involved in lung development ( J:224791 )

• E12.5 lungs show increased mesenchymal proliferation

lung cyst ( J:224791 )

• E14.5 and E16.5 lungs show cystic expansion of the epithelial ducts

enlarged lung ( J:224791 )

• lungs are larger at E12.5 but are similar in size to controls at E14.5 and E16.5

abnormal branching involved in lung morphogenesis ( J:224791 )

• E12.5, E14.5, and E16.5 lungs exhibit reduced branching

abnormal lung-associated mesenchyme development ( J:224791 )

• E12.5 lungs exhibit expanded mesenchyme

abnormal lung epithelium morphology ( J:224791 )

• E12.5 lungs exhibit dilated epithelial ducts

• E14.5 and E16.5 lungs show cystic expansion of the epithelial ducts

cellular

increased mesenchymal cell proliferation involved in lung development ( J:224791 )

• E12.5 lungs show increased mesenchymal proliferation

growth/size/body

lung cyst ( J:224791 )

• E14.5 and E16.5 lungs show cystic expansion of the epithelial ducts

enlarged lung ( J:224791 )

• lungs are larger at E12.5 but are similar in size to controls at E14.5 and E16.5