Phenotypes Associated with This Genotype

Genotype
MGI:5751475

• Allelic Composition: \Cd177^{tm1(KOMP)Vlcg}/\Cd177^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:225335 )

N • mice exhibit normal T and B cell frequencies and myeloid lineages

decreased neutrophil cell number ( J:225335 )

• decreased Itgam+ Ly6c1+ Ly6g+ circulating neutrophils

• decreased 1 day after Staphylococcus aureus skin infection but not after 7 days

• however, numbers are normal in the spleen, lymph nodes and bone marrow and normal after thioglycollate-induced peritonitis

decreased monocyte cell number ( J:225335 )

• decreased Itgam+ Ly6c1+ Ly6g- monocytes 1 day after Staphylococcus aureus skin infection, but not after 3 or 7 days

• however, numbers are normal after thioglycollate-induced peritonitis

abnormal neutrophil physiology ( J:225335 )

• increased cell death in the bone marrow

• however, chemotaxis is normal

hematopoietic system

decreased neutrophil cell number ( J:225335 )

• decreased Itgam+ Ly6c1+ Ly6g+ circulating neutrophils

• decreased 1 day after Staphylococcus aureus skin infection but not after 7 days

• however, numbers are normal in the spleen, lymph nodes and bone marrow and normal after thioglycollate-induced peritonitis

decreased monocyte cell number ( J:225335 )

• decreased Itgam+ Ly6c1+ Ly6g- monocytes 1 day after Staphylococcus aureus skin infection, but not after 3 or 7 days

• however, numbers are normal after thioglycollate-induced peritonitis

abnormal neutrophil physiology ( J:225335 )

• increased cell death in the bone marrow

• however, chemotaxis is normal