Phenotypes Associated with This Genotype

Genotype
MGI:5751123

• Allelic Composition: Htr2c^tm1Arte/Y
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:228775 )

♂N • mice exhibit normal daily wheel running activity, locomotor response to a specific 5-hydroxytryptamine 2C agonist (RO 60-0175) and anxiety-type behaviors

impaired passive avoidance behavior ( J:228775 )

♂ • reduced latency to enter the dark compartment following a mild electric foot shock

increased coping response ( J:228775 )

♂ • reduced time immobile in a forced swim test

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:228775 )

♂N • mice exhibit normal corticosterone response to chronic stress

increased circulating corticosterone level ( J:228775 )

♂ • increase in nadir plasma corticosterone levels

♂ • however, peak levels are normal